Disruption of the oligodendroglial miR-126a-3p- Pex5 axis inhibits remyelination in chronic demyelinating lesions - PubMed
4 hours ago
- #microRNA
- #multiple sclerosis
- #remyelination
- miR-126a-3p is enriched in oligodendroglia from chronic MS plaques and EAE lesions.
- miR-126a-3p inhibits OPC differentiation and remyelination by targeting Pex5 transcripts.
- Deletion of miR-126a-3p in oligodendroglia accelerates remyelination in demyelination models.
- Ganciclovir, identified via Pex5 screening, promotes remyelination after demyelinating events.
- The miR-126a-3p-Pex5 axis is a potential therapeutic target for chronic MS lesions.