Intracellular bacteria modulate the immune microenvironment of oral squamous cell carcinoma - PubMed
a day ago
- #immunotherapy
- #OSCC
- #microbiota
- Intracellular bacteria influence the immune microenvironment in oral squamous cell carcinoma (OSCC).
- Neoadjuvant immune checkpoint blockade (NICB) therapy is effective in OSCC, but the role of intracellular microbiota is unclear.
- INVADEseq technology captures host single-cell RNA sequencing data and bacterial signatures.
- Intracellular bacteria inhibit PDCD1 expression, enhance infection responses, and promote antigen presentation and macrophage activation.
- Key bacterial genera (Fusobacterium, Streptococcus, Capnocytophaga) are linked to increased risks and adverse outcomes in immunotherapy.
- GZMK+ CD8+ T cells and ZBTB16+ TAMs are markers of complete response to NICB.
- Intracellular bacteria weaken communication between cDC1 and immune cells, potentially reducing therapy efficacy.
- The study provides a foundation for understanding how intracellular bacteria mediate NICB responses in OSCC.