The redox paradox in HGGs: ROS as drivers and destroyers - PubMed
a day ago
- #ROS
- #oxidative stress
- #glioblastoma
- Reactive oxygen species (ROS) act as both drivers and destroyers in high-grade gliomas (HGGs).
- ROS deregulation in HGGs promotes tumor growth, therapeutic resistance, DNA damage, and immune escape.
- Oxidative stress in diffuse midline glioma (DMG) leads to global DNA and histone hypomethylation.
- ROS-dependent signaling pathways like Ras/Raf/MAPK and PI3K/Akt/mTOR reinforce tumor survival.
- Excess ROS can overwhelm cellular defenses, creating an intrinsic vulnerability in cancer cells.
- New therapeutic strategies include NADPH oxidase inhibition, metabolic modulation, and ROS-inducing therapies.
- Understanding the redox paradox is key to identifying therapeutic vulnerabilities in HGGs.