Dual-responsive antibacterial hydrogels encapsulating PDLSCs for macrophage reprogramming and diabetic wound healing - PubMed
3 hours ago
- #stem cell therapy
- #diabetic wound healing
- #responsive hydrogels
- Dual-responsive antibacterial hydrogels encapsulating PDLSCs designed for diabetic wound healing.
- Hydrogel composed of GT-PBA, OPU, EGCG, and TOB enables pH/ROS-responsive drug release.
- PDLSCs within the hydrogel maintain high viability and proliferative capacity.
- Hydrogel scavenges ROS, reprograms macrophages, and enhances stem cell survival under oxidative stress.
- Significantly accelerates wound closure, promotes angiogenesis, and modulates inflammation in diabetic models.
- Reduces scar formation and downregulates profibrotic genes YAP and En1.
- Promising strategy for scarless diabetic wound repair through immunomodulation and stem cell delivery.