Periconceptional Use of Analgesics and Severity of Structural Birth Defects - PubMed
3 hours ago
- #birth defects
- #analgesics
- #pregnancy
- Study examines associations between periconceptional use of specific analgesics and severity of structural birth defects.
- Severity groups were created based on 12-month survival rates: <95% survival, <70% survival, and ≥95% survival.
- Acetaminophen as a single component or with cough/cold agents showed no association with birth defect severity.
- Elevated risks for <70% survival birth defects were linked to acetaminophen combined with aspirin, caffeine, hydrocodone, codeine, or propoxyphene.
- Hydrocodone alone showed a significant association (OR: 2.45) with severe birth defects (<70% survival).
- Ibuprofen, naproxen, and aspirin showed modest associations (aORs 1.15-1.28) with birth defect severity.
- Findings suggest safer and riskier analgesic options exist when considering birth defect severity.