Chemotherapy-induced senescent nasopharyngeal carcinoma cells suppress NK cell-mediated antitumor immunity by upregulating EBI3 via mtDNA-cGAS-STING pathway - PubMed
8 hours ago
- #Chemotherapy-induced senescence
- #mtDNA-cGAS-STING pathway
- #NK cell immunity
- Chemotherapy-induced senescent nasopharyngeal carcinoma cells upregulate EBI3 via the mtDNA-cGAS-STING pathway.
- This upregulation suppresses NK cell-mediated antitumor immunity.
- The study highlights a mechanism where senescence in cancer cells impairs immune response.
- Findings suggest potential therapeutic targets to counteract immunosuppression in nasopharyngeal carcinoma.