Weiyan Tongluo Granules attenuate gastric intestinal metaplasia through PPARγ/NF-κB/CDX2 signaling pathway - PubMed
3 hours ago
- #PPARγ/NF-κB/CDX2 Pathway
- #Gastric Intestinal Metaplasia
- #Traditional Chinese Medicine
- Weiyan Tongluo Granules (WYTLG) attenuate gastric intestinal metaplasia (GIM), a precancerous condition.
- WYTLG works through the PPARγ/NF-κB/CDX2 signaling pathway.
- The study used in vivo, in vitro, and in silico methods to evaluate WYTLG's effects.
- 29 components were identified in WYTLG, showing dose-dependent improvement in GIM in rat models.
- WYTLG treatment improved gastric function, reduced inflammation, and enhanced resistance to apoptosis.
- Transcriptomic analysis highlighted the PPARγ/NF-κB pathway as key to WYTLG's effects.
- Molecular docking showed strong binding between WYTLG components and pathway targets.
- The study suggests WYTLG as a potential strategy to prevent gastric malignant transformation.