IDO1 regulating ROS rhythm reveals glycogenolysis/PPP as a cancer treatment target - PubMed
7 hours ago
- #Cancer therapy
- #ROS dynamics
- #IDO1
- ROS dynamics show rhythmic oscillations in cancer cells, influencing tumorigenesis and therapy responses.
- IDO1 degrades under low-ROS conditions but forms an active enzyme with heme in high-ROS conditions, promoting ROS clearance.
- Hypoxic tumor environments lose ROS rhythmicity, activating glycogenolysis via sulfenylated AhR to manage ROS levels.
- Dual inhibition of IDO1 and AhR extends survival in mice, suggesting a therapeutic strategy targeting ROS rhythm disruption.