A multifunctional pearl powder-incorporated scaffold for bone regeneration: Simultaneous enhancement of osteogenesis, immune modulation, and angiogenesis - PubMed
9 hours ago
- #bone regeneration
- #biomimetic scaffold
- #angiogenesis
- A novel biomimetic composite scaffold was developed for bone regeneration, integrating GelMA, pearl powder (PP), and dimethyloxalylglycine (DMOG).
- The scaffold features a well-defined interconnected porous structure with high porosity (62.2%-81.5%) and favorable swelling characteristics.
- In vitro tests showed enhanced stem cell osteogenic differentiation and effective modulation of macrophage polarization towards the pro-regenerative M2 phenotype.
- The scaffold promoted endothelial cell migration and capillary network formation, indicating strong angiogenic properties.
- In vivo studies in a rat femoral condyle defect model demonstrated accelerated bone regeneration, immune modulation, and enhanced angiogenesis.
- The scaffold's multifunctional properties make it a promising solution for clinical bone tissue regeneration.