Large-scale profiling of blood microbial signatures in patients with Parkinson's disease and its association with disease progression: a cross-sectional study - PubMed
4 hours ago
- #Biomarkers
- #Parkinson's disease
- #Microbial signatures
- Study profiles blood microbial signatures in Parkinson's disease (PD) patients.
- Analyzed 4018 whole-genome sequencing (WGS) data from two cohorts.
- Identified 126 bacterial species as key signatures in PD, with 19 showing increased abundance.
- Microbial signatures correlated with severe clinical manifestations like motor dysfunction and cognitive impairment.
- Findings suggest blood microbial signatures could serve as PD biomarkers.
- Study funded by Hunan Innovative Province Construction Project, National Natural Science Foundation of China, and Natural Science Foundation of Hunan Province.