Translational selenium nanoparticles trigger apoptosis in triple-negative breast cancer cells through the MAPKs/Bcl2 pathway - PubMed
4 hours ago
- #Nanoparticles
- #Apoptosis
- #Breast Cancer
- Selenium nanoparticles modified with a mushroom polysaccharide-protein complex (PTR-SeNPs) show anti-tumor efficacy in triple-negative breast cancer (TNBC) cells.
- PTR-SeNPs induce mitochondrial-dependent apoptosis via the MAPKs/Bcl2 pathway, and conjugation with anti-MUC1 antibodies enhances activity in MUC1-expressing TNBC lines.
- Oral administration of MUC1@PTR-SeNPs inhibits tumor growth in mouse xenograft models through mitochondria-mediated apoptosis, highlighting therapeutic potential for TNBC.