Tetrahedral Framework Nucleic Acid-Puerarin Complex Alleviates Osteoporosis Through the FXR/Runx2 Axis - PubMed
3 hours ago
- #osteoporosis
- #puerarin
- #nanocomplex
- Osteoporosis is common, but current treatments are inconvenient and have side effects.
- Puerarin (Pue) shows potential for osteoporosis but has poor solubility, low bioavailability, and instability.
- A tetrahedral framework nucleic acid-puerarin complex (TPC) was synthesized to enhance Pue's delivery and stability.
- TPC improves cellular uptake, osteogenic activity, and anti-osteoporosis effects compared to Pue alone.
- The therapeutic effects are mediated through the FXR/Runx2 pathway.