Reactivating exhausted tumor-infiltrating T cells by a bispecific DC-T cell engager in mice - PubMed
3 hours ago
- #immunotherapy
- #bispecific engager
- #T cell exhaustion
- Tumor-infiltrating T cells (TILs) play a crucial role in anti-tumor immune responses but become exhausted due to chronic antigen exposure.
- A bispecific DC-T cell engager (BiDT) was developed to target TIM3 on exhausted TILs and activate dendritic cells (DCs) via IFNAR receptor.
- BiDT reactivates exhausted TILs by preventing apoptosis (via increased Bcl-2) and enhances DC function through IL-2 signaling and CD80/86-CD28 interactions.
- A Pro-BiDT engager with pro-IFNα was engineered to reduce systemic toxicity while maintaining potent antitumor activity.
- BiDT treatment strengthens DC-T cell communication pathways, essential for effective anti-tumor immunity.