Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis - PubMed
7 days ago
- #Mycobacterium tuberculosis
- #Metal Resistance
- #Effluxosomes
- Mycobacterium tuberculosis uses membrane-associated effluxosomes to resist multiple metals.
- PacL proteins (PacL1, PacL2, PacL3) organize P-type ATPase pumps (CtpC, CtpG, CtpV) into functional effluxosomes.
- Single-particle tracking shows PacL proteins integrate into slower-moving effluxosomes.
- PacL1 acts as a multi-substrate metallochaperone, binding zinc, cadmium, and copper via a conserved C-terminal motif.
- Super-resolution microscopy identifies essential residues in the PacL transmembrane domain for effluxosome assembly.
- Proximity labeling reveals PacL1 interacts with a broad network, suggesting effluxosomes aid in stress adaptation.
- Effluxosomes represent a new target for antimicrobial strategies against M. tuberculosis.