GSK-3β coordinates axonal microtubule organization through Shot and Tau - PubMed
5 days ago
- #GSK-3β
- #microtubules
- #neurodegeneration
- GSK-3β is crucial for neuronal development and maintenance, with hyperactivity linked to neurodevelopmental and neurodegenerative diseases.
- Proper regulation of GSK-3β kinase activity is essential for maintaining parallel microtubule bundles in axons.
- Dysregulation of GSK-3β (either up or down) leads to pathological axonal swellings and disorganized microtubules.
- Microtubule bundling proteins Shot and Tau are key targets of GSK-3β, influencing their attachment to microtubules and Eb1.
- GSK-3β misregulation disrupts Eb1-Shot-mediated guidance of microtubules, causing disorganization.
- Microtubule disorganization due to GSK-3β dysregulation may explain the failure of global GSK-3β inhibition in clinical trials.