Progressive multifocal leucoencephalopathy as a rare complication of anti-synthetase syndrome associated with immunosuppressive therapy - PubMed
4 hours ago
- #immunosuppressive therapy
- #anti-synthetase syndrome
- #PML
- A woman in her late 50s with anti-synthetase syndrome developed progressive multifocal leucoencephalopathy (PML), a rare complication of immunosuppressive therapy.
- She presented with transient left-sided paraesthesia, left hand weakness, incoordination, and blurry vision, initially suspected as a cerebrovascular event.
- Imaging showed multifocal subcortical white matter lesions, and brain biopsy confirmed PML.
- She was treated with mycophenolate mofetil and low-dose prednisolone, without rituximab.
- Symptoms improved after stopping immunosuppressive therapy.
- This case emphasizes considering PML in immunosuppressed patients with neurological symptoms, even without monoclonal antibody exposure.
- Suggests a possible link between conventional immunosuppressive therapy and PML, though causality is not confirmed.