Dual-function oral nanotherapeutic mitigates sepsis-like multi-organ failure by targeting inflammatory and fibrotic pathways - PubMed
a day ago
- #Sepsis
- #Multi-organ failure
- #Nanoparticle
- Development of a dual-function nanoparticle, P2Ns-NAR(NAR), using naringenin (NAR) for targeting gut folate receptors and as a therapeutic agent.
- Significant reduction in pro-inflammatory, apoptotic, fibrosis, and inflammasome-related markers in a mouse model of LPS-induced sepsis.
- Prevention of tissue injury in multiple organs (lungs, liver, kidney, heart, brain, intestines, spleen) and reduction in collagen deposition.
- Demonstration of the nanoparticle's efficacy as an oral therapy to prevent multi-organ failure in sepsis.