Metabolic Bariatric Surgery versus GLP-1 Receptor Agonists for Obesity Management: A Systematic Review and Meta-Analysis - PubMed
3 hours ago
- #Bariatric Surgery
- #GLP-1 Receptor Agonists
- #Obesity
- Metabolic Bariatric Surgery (MBS) and GLP-1 Receptor Agonists (GLP-1 RAs) are compared for obesity management.
- MBS shows significantly greater total weight loss (TWL) and BMI reduction compared to GLP-1 RA therapy.
- The study includes 5 retrospective observational studies with 5,944 participants.
- MBS is confirmed as the most effective intervention for severe obesity with durable weight loss.
- GLP-1 RAs are valuable as noninvasive or adjunctive options but less effective than surgery.
- Risk of bias was moderate due to non-randomized designs and treatment selection bias.
- Certainty of evidence was rated as moderate.