IL-22 induces Paneth cell metaplasia in the colonic epithelium of ulcerative colitis, promoting wound healing via REG3A - PubMed
3 hours ago
- #Ulcerative Colitis
- #Paneth Cell Metaplasia
- #IL-22
- IL-22 induces Paneth cell metaplasia (PCM) in the colonic epithelium of ulcerative colitis (UC).
- PCM correlates with disease duration and active inflammation in UC patients.
- IL-22 promotes PCM by suppressing Notch signaling and inducing REG3A expression.
- REG3A enhances cell proliferation and promotes wound healing in mouse and human colonic organoids.
- In vivo, Reg3a-deficient mice show delayed wound healing in colitis models.
- REG3A has a protective role in the colonic epithelium of UC patients.