Mouse germline cysts contain a fusome-like structure that mediates oocyte development - PubMed
12 hours ago
- #fusome
- #oocyte development
- #germline cyst
- Mouse female primordial germ cells (PGCs) undergo five synchronous, incomplete mitotic divisions.
- The resulting germline cyst fragments to produce 4-6 oocytes and 24-26 nurse cells.
- A fusome-like structure, similar to Drosophila's, is found in mouse germline cysts.
- This fusome distributes asymmetrically, enriching in future oocytes with Pard3 and Golgi-endosomal UPR proteins.
- Spindle remnants rich in stable acetylated microtubules transiently link early mouse cyst cells.
- A non-random gap in microtubules predicts cyst fragmentation into six-cell derivatives.
- The polarized fusome is crucial for female gamete development from PGC to follicular oocyte stages.