Oligodendrocyte-encoded lactate dehydrogenase A couples glycolysis to remyelination via protein lactylation - PubMed
3 hours ago
- #glycolysis
- #lactylation
- #demyelinating disease
- Oligodendrocytes (OLs) in demyelinating lesions show reduced glycolytic efficiency and lactate production.
- Lactate administration or overexpression of lactate dehydrogenase A (LDHA) in Olig1+ OLs enhances remyelination.
- Conditional knockout of LDHA in Olig1+ or CNPase+ OLs leads to severe neuropathy and dysmyelination.
- OLs in demyelinating lesions undergo lactylation silencing, which hinders myelin restoration.
- Lactylation of LDHA and carbonic anhydrase II (CAII) links glycolysis with OL maturation.
- The study provides new enzymatic therapeutic perspectives for demyelinating disorders.