Cell-free fat extract attenuates temporomandibular joint osteoarthritis via repressing ATF3-binding chromatin accessibility - PubMed
4 hours ago
- #TMJOA
- #epigenetic regulation
- #CEFFE
- Cell-free fat extract (CEFFE) shows therapeutic potential for temporomandibular joint osteoarthritis (TMJOA).
- CEFFE enhances chondrocyte proliferation, reduces inflammation, and maintains extracellular matrix homeostasis.
- CEFFE works by repressing ATF3-binding chromatin accessibility, inhibiting NF-κB signaling.
- In a rat model, CEFFE alleviates cartilage degeneration, bone loss, and synovitis without toxicity.
- CEFFE also reduces M1 macrophage polarization and pro-inflammatory cytokine expression in synovial tissue.
- The study highlights CEFFE as a dual-target agent with regenerative and anti-inflammatory effects.