Augmenting the Endogenous RBM3 Response Protects Against Burn-Induced Acute Kidney Injury by Enhancing Macrophage-Mediated Resolution of Inflammation - PubMed
3 hours ago
- #macrophage polarization
- #acute kidney injury
- #RBM3
- The study investigates how RBM3 modulates macrophage function to alleviate burn-induced acute kidney injury (AKI).
- A standardized scald burn model in rats showed peak AKI severity at 48 hours post-burn, with dynamic RBM3 expression.
- RBM3 overexpression improved renal function, reduced inflammation (IL-6, IL-1β, TNF-α), promoted M2 macrophage polarization, and enhanced efferocytosis.
- Slfn4 knockdown replicated RBM3's protective effects, while RBM3 inhibition worsened M1 polarization, which was rescued by Slfn4 suppression.
- The RBM3-Slfn4 axis is identified as a potential therapeutic target for managing AKI by driving a pro-resolving macrophage program.