Effects of subcutaneous and sublingual allergen immunotherapy on immune responses in children with bronchial asthma - PubMed
4 hours ago
- #immunotherapy
- #pediatrics
- #allergic asthma
- Allergic asthma in children affects quality of life, with SCIT and SLIT emerging as effective treatments.
- The study compared SCIT, SLIT, and ICS in 86 children (5-12 years) with allergic asthma.
- All groups showed improved C-ACT scores and FEV1% after one year, with SCIT and SLIT outperforming ICS.
- SCIT and SLIT groups exhibited significant changes in immune markers (Th17, Treg, IL-17, IL-9, IL-10), unlike ICS.
- No significant differences in immune markers were found between SCIT and SLIT post-treatment.
- SCIT and SLIT combined with ICS are more effective than ICS alone, likely due to shared immune tolerance mechanisms via Treg cells.