Associations of eight insulin resistance-related indices and genetic risk with incident cardiometabolic multimorbidity among participants with hypertension: a large prospective cohort study - PubMed
8 hours ago
- #Hypertension
- #Insulin Resistance
- #Cardiometabolic Multimorbidity
- Eight insulin resistance (IR)-related indices (TyG index, TyG-BMI, TyG-WC, TyG-WHtR, TyG-ABSI, TyG-WWI, TyG-BRI, TG-HDL-C) are associated with an elevated risk of incident cardiometabolic multimorbidity (CMM) in hypertensive patients, with TyG-WHtR showing the strongest predictive performance.
- High levels of IR-related indices and high genetic risk jointly increase CMM risk, with additive and multiplicative interactions indicating that genetic risk strengthens the adverse effects of IR.
- Systemic inflammation, hepatic, and renal biomarker abnormalities may partially mediate the associations between IR-related indices and CMM, suggesting underlying biological pathways.
- The study uses data from 129,853 hypertensive patients in the UK Biobank over a 13-year follow-up, recording 28,455 CMM events and employing Cox models and predictive metrics (net reclassification improvement, integrated discrimination improvement, C index) for analysis.
- Findings support the use of IR-related indices, particularly TyG-WHtR, for risk stratification of CMM in hypertensive populations to aid in prevention and management strategies.