Fungus Derived Indole-3-Acetic Acid Controls Developmental Conidial Death in Magnaporthe oryzae - PubMed
3 hours ago
- #Ferroptosis
- #Indole-3-Acetic Acid
- #Plant Pathology
- Elevated indole-3-acetic acid (IAA) promotes iron and lipid peroxide accumulation, leading to increased ferroptotic death in Magnaporthe oryzae conidia.
- Conidial death positively correlates with endogenous IAA levels; IAA biosynthesis mutant tam1Δ shows altered conidial death.
- IAA-dependent lipid metabolism gene mutant ppoΔ exhibits deficiencies in conidial death, delayed appressorium formation, and reduced pathogenicity.
- Exogenous phosphatidylethanolamines (DOPE and SLPE) partially restore defects in tam1Δ and ppoΔ mutants, indicating IAA affects lipid metabolism/peroxidation.
- TAM1 modulates ATG8 transcription, influencing autophagy, revealing a link between IAA, ferroptosis, and pathogenic development in rice blast fungus.
- M. oryzae uses IAA to trigger ferroptotic conidial death, enhancing pathogenicity, suggesting IAA synthesis inhibitors as potential control strategy.