Redox Dual-Responsive Drug Delivery System with Cascade of Reactive Oxygen Species Self-Generation for Enhanced Cancer Chemotherapy - PubMed
4 hours ago
- #tumor therapy
- #ROS generation
- #nano-drug delivery
- Development of CASS@PTX nanoparticles for cancer chemotherapy.
- Dual-responsive to glutathione (GSH) depletion and reactive oxygen species (ROS) amplification.
- Enhances chemotherapeutic efficacy by disrupting redox homeostasis in tumor cells.
- Triggers paclitaxel (PTX) release and promotes apoptosis via ROS overproduction.
- Preclinical validation shows potent anti-tumor effects with minimal systemic toxicity.
- Potential to overcome multidrug resistance in cancer therapy.