Particles that enhance mRNA delivery could reduce vaccine dosage and costs
14 days ago
- #vaccine delivery
- #mRNA vaccines
- #nanoparticles
- MIT researchers developed a new lipid nanoparticle (LNP) called AMG1541 for mRNA vaccine delivery.
- The new LNP can generate the same immune response as FDA-approved LNPs at 1/100 the dose in mice.
- AMG1541 improves endosomal escape and biodegradability, reducing potential side effects.
- The LNP enhances delivery to antigen-presenting cells and accumulates more in lymph nodes.
- Potential applications include flu, Covid-19, and other infectious disease vaccines.
- Lower doses could reduce vaccine costs and improve strain-matching for seasonal flu vaccines.