A comparative analysis of CD70-directed CAR-T cells for glioblastoma treatment demonstrates a superior efficacy of the ligand-based construct - PubMed
2 days ago
- #immunotherapy
- #CAR-T cells
- #glioblastoma
- CD70 is a target for CAR-T cell therapy in glioblastoma (GB) due to its role in tumor growth and immunosuppression.
- Comparative analysis of CD70-directed CAR-T cells showed the ligand-based construct (CD27z) had superior efficacy.
- CD27z CAR-T cells secreted the highest levels of Th1 cytokines and demonstrated potent antitumor activity in vitro and in vivo.
- The study supports the incorporation of CD27-based CAR designs into clinical trials for recurrent GB.