Vaccinia virus armed with IL-21 can cure murine colorectal cancer liver metastases via intravenous administration - PubMed
3 hours ago
- #Oncolytic Virus
- #Colorectal Cancer Metastases
- #Immunotherapy
- VVLΔTK-STCΔN1L-mIL21, an oncolytic vaccinia virus expressing IL-21, successfully reaches liver metastases via intravenous administration in a murine colorectal cancer model.
- Intravenous treatment with VVLΔTK-STCΔN1L-mIL21 significantly extends survival in mice with colorectal cancer liver metastases (CRLM).
- The virus promotes expansion of CD8+ T cells and effector memory T cells, reduces regulatory T cells, and enhances IFN-γ secretion in vitro.
- Therapy inhibits immune checkpoint molecules on CD8+ T cells and supports the generation of T follicular helper cells.
- The study highlights the feasibility of systemic oncolytic virus delivery for treating distant tumors, broadening potential clinical applications.