The splenic norepinephrine-β2-adrenergic receptor axis aggravates sepsis-associated acute kidney injury via neutrophil-mediated immunosuppression - PubMed
3 hours ago
- #acute kidney injury
- #neutrophil
- #sepsis
- The splenic norepinephrine-β2-adrenergic receptor (NE/β2-AR) axis worsens sepsis-associated acute kidney injury (SA-AKI) through neutrophil-mediated immunosuppression.
- Pre-emptive splenic denervation in mice reduces sepsis-induced kidney injury, while local intrasplenic norepinephrine infusion worsens kidney damage.
- Blocking splenic β2-adrenergic receptor (β2-AR) signaling improves survival and reduces kidney damage in a cecal ligation/puncture (CLP) mouse model.
- NE/β2-AR signaling affects splenic neutrophils, promoting acute sepsis progression by enhancing prostaglandin E2 synthesis via the cAMP-response element binding protein pathway.
- This mechanism suppresses T helper 1 cell activation, increases bacterial infections, and aggravates SA-AKI.