Compressive stress-driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progression via epigenetic mechanical memory - PubMed
8 hours ago
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- #Piezo1
- #Mechanotransduction
- Compressive stress activates Piezo1, promoting Rho-ROCK mechanotransduction and tumor progression.
- Piezo1-Rho-ROCK axis generates intracellular forces to counteract tumor tissue stress, enhancing malignancy.
- Silencing Piezo1 stops compression-induced Rho-ROCK activation and tumor growth in models.
- High PIEZO1 levels correlate with 35% worse survival in breast cancer patients.
- Compressive forces induce epigenetic mechanical memory via Piezo1-Rho-ROCK, altering histone modifications.
- ROCK-dependent histone changes promote open chromatin, regulating cancer-related gene expression.
- PIEZO1-RHO-ROCK axis links tissue forces to persistent epigenetic tumor-promoting changes.