Clinical outcomes and haemodynamic response after blinded stress assessment of moderate aortic stenosis - PubMed
4 hours ago
- #haemodynamics
- #clinical outcomes
- #aortic stenosis
- Study evaluates symptomatic patients with moderate aortic stenosis (AS) and preserved left ventricular ejection fraction (LVEF).
- Stress aortic valve index (SAVI) showed modest agreement with echocardiographic parameters but was associated with clinical outcomes.
- Invasive transvalvular gradient increased from 25±9 mmHg at rest to 42±14 mmHg during dobutamine stress.
- 48% of patients demonstrated a SAVI ≤0.70, comparable to severe AS.
- SAVI independently predicted the need for clinical aortic valve intervention (hazard ratio 5.7; p=0.007).
- Stress haemodynamic assessment identifies a high-risk subgroup not detected by conventional metrics.