Immunity to hemagglutinin and neuraminidase results in additive reductions in airborne transmission of influenza H1N1 virus in ferrets - PubMed
4 hours ago
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- Immunity to both hemagglutinin (HA) and neuraminidase (NA) results in additive reductions in airborne transmission of influenza H1N1 virus in ferrets.
- Combined immunity to HA and NA leads to the largest reductions in transmission compared to immunity to either antigen alone.
- The study found no emergence of escape variants during transmission studies.
- A threshold viral titer was identified (10^1.5 and 10^2 median tissue culture infectious dose per ml on days 1 and 3 postinfection, respectively) indicative of decreased transmission.
- The research provides insights into the relationship between immunity to HA and NA and influenza virus transmission.