Standardized chronic restraint stress protocols reveal dynamic evolution of behavioral adaptations in male mice: implications for translational neuroscience - PubMed
10 hours ago
- #behavioral neuroscience
- #chronic stress
- #translational research
- Short-duration, high-intensity CRS (6h/day for 3 days) induces persistent avoidance-related and repetitive behaviors in male mice.
- Prolonged CRS (2h/day for 10-14 days) leads to progressive deficits in reward-seeking and behavioral coping, transitioning from initial avoidance/repetitive behaviors.
- The 10-day CRS protocol is critical for inducing comorbid avoidance and reward-processing impairments, serving as a model for stress-related disorders.
- Ketamine reverses reward-seeking and coping deficits, while paroxetine alleviates both repetitive/avoidance behaviors and reward-seeking/coping impairments.
- The study validates CRS as a model with face, construct, and predictive validity for translational neuroscience, offering standardized protocols for chronic stress research.