ChREBP drives β-cell proliferation under metabolic stress but not in pregnancy-induced β-cell expansion - PubMed
4 hours ago
- #β-cell proliferation
- #ChREBP
- #metabolic stress
- ChREBP is a glucose-activated transcription factor involved in β-cell proliferation and metabolic regulation.
- β-cell-specific ChREBP knockout mice show impaired β-cell proliferation under insulin resistance (S961 treatment) and high-fat diet feeding, with decreased Rgs16 expression.
- These knockout mice develop mild early-phase insulin secretion defects and age-related glucose intolerance.
- Pregnancy-induced β-cell proliferation and mitogenic gene expression (e.g., Tph2, Ccnb1, Ccnb2) remain intact in the knockout mice, with unaffected Rgs16.
- ChREBP plays a context-dependent role, critical under metabolic stress but not in normoglycemic pregnancy, suggesting the ChREBP-RGS16 axis as a therapeutic target for type 2 diabetes.