ABI3BP protects against cerebral ischemia-reperfusion injury by preserving blood-brain barrier integrity and activating PI3K/Akt signaling - PubMed
4 hours ago
- #ABI3BP
- #Blood-brain barrier
- #Ischemic stroke
- ABI3BP protects against cerebral ischemia-reperfusion injury (IRI) by preserving blood-brain barrier (BBB) integrity.
- ABI3BP activates PI3K/Akt signaling, which helps in reducing infarct volume and improving neurological scores.
- Thrombin hydrolyzes ABI3BP at arginine 337, and its inhibitor dabigatran reverses ABI3BP reduction post-IRI.
- Recombinant ABI3BP crosses the BBB, restores blood flow, and decreases BBB leakage by upregulating tight junction proteins (ZO-1/Occludin).
- ABI3BP inhibits cleaved caspase-3 expression and increases Bcl-2/Bax ratio, p-Akt/Akt, and p-PI3K/PI3K levels, suppressing endothelial apoptosis.
- Supplementation of recombinant ABI3BP shows therapeutic potential for ischemic stroke by enhancing BBB integrity and tight junction proteins.