DDX21 Links BRAFV600E and TERT to Promote Thyroid Cancer Progression - PubMed
a day ago
- #thyroid cancer
- #DDX21
- #BRAFV600E
- DDX21 interacts with TERT to regulate ribosomal RNA (rRNA) transcription by affecting Pol I binding to rDNA.
- DDX21 is upregulated in thyroid cancer and its knockdown suppresses cancer cell proliferation, migration, and invasion.
- GABPA binds to the DDX21 promoter, and its knockdown reduces DDX21 expression.
- BRAFV600E mutation upregulates DDX21 through the MEK/ERK/GABP axis.
- DDX21 acts as a mediator between BRAFV600E and TERT, promoting thyroid cancer progression.
- DDX21 may serve as a therapeutic target for thyroid cancer with BRAF and TERT alterations.