Inositol and Berberine Synergistically Reprogram Endocrine and Ovarian Metabolism in Polycystic Ovary Syndrome - PubMed
3 hours ago
- #PCOS
- #Inositol
- #Berberine
- Inositol (Myo-Inositol/D-Chiro-Inositol) and Berberine (BBR) show superior combined efficacy in treating PCOS compared to single treatments.
- The combination restores sex steroid balance, normalizes LH/FSH ratio, and improves estrous cyclicity in a DHEA+HFD-induced mouse model.
- Ins/BBR reduces ovarian cysts, enhances fertility, and partially normalizes steroidogenic enzyme expression.
- At the cellular level, Ins/BBR alleviates mitochondrial defects and reprograms metabolic landscape in granulosa cells.
- The treatment restores nucleotide pools, amino acid turnover, and prevents abnormal long-chain fatty acid accumulation.
- Ins/BBR acts through coordinated endocrine, ovarian, and metabolic mechanisms, offering a safe and effective therapeutic strategy for PCOS.