Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin signaling to promote mitophagy and attenuate inflammation in chondrocytes - PubMed
a day ago
- #mitophagy
- #Sirt3
- #osteoarthritis
- Homoplantaginin (Homo) shows potential in treating osteoarthritis (OA) by activating the Sirt3/PINK1/Parkin signaling pathway.
- Homo reduces cartilage degradation, improves extracellular matrix metabolism, and enhances chondrocyte viability.
- The study identifies Sirt3 as a direct target of Homo, which promotes mitophagy and restores mitochondrial function.
- Both in vivo (ACLT mouse model) and in vitro (LPS-induced chondrocytes model) experiments confirm Homo's therapeutic effects.
- Transcriptomics and molecular analyses reveal mitophagy as a key mechanism behind Homo's benefits in OA treatment.