A non-transcriptional mitotic function of POU/Oct factors ensures spindle assembly and chromosome segregation - PubMed
3 hours ago
- #Spindle assembly
- #Mitosis
- #POU/Oct factors
- POU/Oct transcription factors, including Nub/Pdm1 (Drosophila) and POU2F1/Oct1 (human), play a non-transcriptional role in mitosis.
- Depletion of Nub/Pdm1 in Drosophila and POU2F1/Oct1 in human cells leads to disorganized spindles, aberrant chromosome segregation, and delayed mitosis.
- Nub/Pdm1 localizes to mitotic spindles independently of DNA binding, relying on microtubule integrity, motor proteins, and kinases.
- This study reveals a novel mitotic function of POU/Oct proteins in spindle stability and elongation, linking them to potential oncogenic properties.