Prognostic Value of NT-proBNP in Patients Undergoing Tricuspid Valve Transcatheter Edge-to-Edge Repair: The EuroTR Registry - PubMed
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- #NT-proBNP
- #tricuspid regurgitation
- #T-TEER
- NT-proBNP is a marker of myocardial stress, but its prognostic role in tricuspid valve transcatheter edge-to-edge repair (T-TEER) was unclear.
- The study evaluated baseline NT-proBNP and its early post-procedural trajectory in patients undergoing T-TEER.
- Higher baseline NT-proBNP tertiles were linked to greater comorbidity burden, advanced biventricular remodeling, and more severe tricuspid regurgitation (TR).
- Baseline NT-proBNP independently predicted a 2-year composite endpoint of all-cause mortality or heart failure hospitalization (adjusted HR: 1.62).
- Higher NT-proBNP levels were associated with lower likelihood of symptomatic improvement (adjusted OR: 0.58 per log10 increase).
- Both baseline NT-proBNP and higher-than-expected 30-day levels post-procedure were independently linked to higher risk for adverse outcomes.
- Early post-procedural NT-proBNP trajectories provided incremental prognostic information for risk stratification.