The value of Protein Phosphatase Methylesterase 1 in diagnosis, prognosis and immunoregulation: from pan-cancer analysis to breast cancer verification - PubMed
3 hours ago
- #PPME1
- #tumor-immunity
- #breast-cancer
- PPME1 is upregulated in most tumors and shows heterogeneous expression across immune and molecular subtypes.
- High PPME1 levels are an independent risk factor in cancers like BLCA, BRCA, HNSC, KICH, LIHC, and UVM, linked to poor prognosis.
- PPME1 has moderate to high diagnostic accuracy and influences the tumor microenvironment by affecting genomic stability and immune response.
- Functional enrichment analysis reveals PPME1's role in DNA damage/repair, pathway activation, metabolism, protein modification, and immune regulation.
- In breast cancer, PPME1 mRNA and protein levels are higher in tumor tissues than in normal adjacent tissue.
- Suppressing PPME1 inhibits migration, invasion, and tumor growth in breast cancer cells, suggesting it as a potential therapeutic target.
- PPME1 acts as an oncogenic driver in multiple cancers, promoting breast cancer progression via pro-tumorigenic pathways.