Sex differences in chemotherapy-induced neuropathic pain: mechanisms and pharmacotherapy - PubMed
4 hours ago
- #neuropathic pain
- #chemotherapy
- #sex differences
- Chemotherapy-induced peripheral neuropathy (CIPN) exhibits significant sex differences in animal models, molecular mechanisms, and drug responses.
- In female mice, pain sensitivity involves the IL-23/IL-17A/TRPV1 signaling axis, regulated by estrogen and ER-α.
- In male mice, pain is more driven by TLR9-mediated macrophage activation and TNF/CXCL1 release.
- Pharmacotherapy responses vary by sex; for example, duloxetine may be more effective in females.
- Other compounds like KOR agonists, resolvin D5, Mitragynine, S1PR1 antagonists, and A3AR agonists show sex-dependent efficacy.
- Sex is a critical biological variable in CIPN, influencing neuroimmune mechanisms and hormonal regulation.
- Incorporating sex into analgesic development and clinical practice is essential for personalized pain management.