Modeling the evolutionary dynamics of clonal hematopoiesis - PubMed
6 days ago
- #hematopoietic stem cells
- #mathematical modeling
- #clonal hematopoiesis
- Clonal hematopoiesis (CH) arises from somatic mutations in hematopoietic stem and progenitor cells.
- CH is linked to age-related conditions like cardiovascular disease, myeloid neoplasms, and cancer therapy complications.
- Chemotherapy and radiation can accelerate CH expansion, increasing risks of cardiotoxicity and therapy-related myeloid neoplasms.
- Despite its clinical relevance, the long-term dynamics of CH expansion in humans are not well understood.
- Mathematical modeling is crucial for understanding CH evolution, estimating clone fitness, and making patient-level predictions.
- This study reviews current evidence on CH dynamics, compares mathematical models, and discusses clinical management implications.