Comparative effectiveness, safety and acceptability of pharmacological and psychosocial interventions for the treatment of cannabis use disorder: A network meta-analysis - PubMed
19 hours ago
- #network meta-analysis
- #cannabis use disorder
- #treatment interventions
- Network meta-analysis examined effectiveness, safety, and acceptability of pharmacological and psychosocial interventions for cannabis use disorder.
- Low-certainty evidence suggests DBT/ACT and MET-CBT with contingency management may reduce cannabis use frequency compared to non-specific comparators.
- Contingency management-based interventions may support abstinence, though evidence is very low certainty.
- Pharmacotherapies like cannabidiol, N-acetylcysteine, and varenicline might promote abstinence vs. placebo, but some are linked to adverse events.
- Some antidepressants, benzodiazepines, bupropion, and buspirone showed more adverse events without clear effectiveness compared to placebo.
- DBT/ACT and contingency management may improve treatment completion, while MET-CBT with/without affect management could reduce it.
- N-acetylcysteine and delta-9-THC preparations might increase treatment completion, whereas certain inhibitors and SSRIs may decrease it vs. placebo.
- Overall findings are based on low- to very-low-certainty evidence due to imprecision, heterogeneity, and high risk of bias in studies.