Perspectives from machine learning and multi-omics to decoding the effects of VDAC2 malignant subsets on tumor evolution - PubMed
4 hours ago
- #pan-cancer analysis
- #immune evasion
- #VDAC2
- VDAC2 is upregulated in most pan-cancers and involved in energy metabolism, mitochondrial damage, and cell proliferation.
- The VDAC2-BAK1-IFNγ pathway is identified as important for tumor progression and immune evasion, particularly in digestive cancers.
- VDAC2 overexpression promotes gastric cancer cell proliferation, invasion, and immune invasion in vitro.
- VDAC2 serves as a potential prognostic biomarker, screening indicator, and therapeutic target sensitive to various drugs.