Targeting ferroptosis in cancer: from mechanistic insights to therapeutic approaches - PubMed
4 hours ago
- #Immunotherapy
- #Ferroptosis
- #Cancer Therapy
- Ferroptosis is a promising programmed cell death modality for cancer therapy, driven by iron overload and phospholipid peroxides.
- Ferroptosis can suppress tumor growth, especially in therapy-resistant cancer cells and cancer stem cells.
- Key mechanisms include the system Xc–GSH-GPX4, NADPH-FSP1-CoQ10, and GCH1-BH4 pathways.
- Crosstalk exists between ferroptosis and cuproptosis, disulfidptosis, and autophagy.
- Ferroptosis influences the tumor immune microenvironment and responses to immunotherapy.
- Clinical potential includes induction via chemotherapy, radiotherapy, immunotherapy, and nanomedicine.
- Challenges include understanding molecular bases, integrating with conventional therapies, and balancing benefits and risks.