Molecular basis of muscle wasting and emerging therapeutic strategies targeting degenerative muscle disorders - PubMed
3 hours ago
- #Regenerative therapy
- #Muscle wasting
- #Molecular mechanisms
- Muscle degenerative conditions like sarcopenia, muscular dystrophies, and trauma-induced muscle loss impact mobility, metabolism, and health.
- Causes include imbalances in protein homeostasis, satellite cell dysfunction, mitochondrial stress, and chronic inflammation.
- Key molecular regulators include FOXO, AMPK, mTOR, and the myostatin/SMAD axis in muscle atrophy.
- Current regenerative strategies involve stem cell-based therapies, gene editing, exosome delivery, and biomaterial scaffolds.
- Emerging therapies include engineered exosomes, pro-regenerative cytokines, and biomimetic scaffolds for angiogenesis and myogenesis.
- Advances in multi-omics and AI are aiding in identifying molecular targets and personalized interventions.
- Combination therapies integrating cellular, molecular, and structural approaches show synergistic benefits.