Integrated bioinformatics analysis reveals cross-talking hub genes and therapeutic agents between sepsis and acute myocardial infarction - PubMed
3 hours ago
- #AMI
- #bioinformatics
- #sepsis
- Identified 417 common genes between sepsis and acute myocardial infarction (AMI) through bioinformatics analysis.
- Three hub genes—JAK2, MYD88, and TIMP1—were highlighted for their diagnostic and therapeutic potential.
- Functional enrichment analysis showed significant involvement in inflammatory responses.
- ROC curve analysis confirmed strong diagnostic performance of the hub genes for both sepsis and AMI.
- Immune infiltration analysis linked these genes to various immune cell types.
- Molecular docking suggested quercetin as a stable binding agent for the proteins encoded by the hub genes.
- qPCR validation confirmed upregulation of JAK2, MYD88, and TIMP1, supporting quercetin's anti-inflammatory effects.
- Quercetin emerges as a promising therapeutic candidate for both sepsis and AMI.